The antiserum was produced against synthesized peptide derived from human CHP2. AA range:101-150

CHP2 Polyclonal Antibody detects endogenous levels of CHP2 protein.

CHP2

Calcineurin B homologous protein 2

CHP2 ;
HCA520 ;
Calcineurin B homologous protein 2 ;
Hepatocellular carcinoma-associated antigen 520

This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013],

Function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death.,similarity:Contains 4 EF-hand domains.,subunit:Binds to SLC9A1/NHE1.,tissue specificity:Expressed in malignantly transformed cells but not detected in normal tissues.,

Nucleus . Cytoplasm . Cell membrane . Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. .

Expressed in malignantly transformed cells but not detected in normal tissues.