The antiserum was produced against synthesized peptide derived from human PKG2. AA range:92-141

cGKII Polyclonal Antibody detects endogenous levels of cGKII protein.

PRKG2

cGMP-dependent protein kinase 2

PRKG2 ;
PRKGR2 ;
cGMP-dependent protein kinase 2 ;
cGK 2 ;
cGK2 ;
cGMP-dependent protein kinase II ;
cGKII

This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Binding of cGMP results in enzyme activation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 cyclic nucleotide-binding domains.,tissue specificity:Highly concentrated in brain, lung and intestinal mucosa.,

Apical cell membrane ; Lipid-anchor .

Highly concentrated in brain, lung and intestinal mucosa.

>>cGMP-PKG signaling pathway ;
>>Gap junction ;
>>Platelet activation ;
>>Circadian entrainment ;
>>Thermogenesis ;
>>Long-term depression ;
>>Olfactory transduction ;
>>Regulation of lipolysis in adipocytes ;
>>Renin secretion ;
>>Salivary secretion