Catalog: YT0874
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
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Main Information
Target
CES2
Host Species
Rabbit
Reactivity
Human
Applications
WB, IHC, IF, ELISA
MW
61kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
CES2 Polyclonal Antibody detects endogenous levels of CES2 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
61kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from the Internal region of human CES2.
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Specificity:
CES2 Polyclonal Antibody detects endogenous levels of CES2 protein.
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Gene Name:
CES2
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Protein Name:
Cocaine esterase
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Other Name:
CES2 ;
ICE ;
Cocaine esterase ;
Carboxylesterase 2 ;
CE-2 ;
hCE-2 ;
Methylumbelliferyl-acetate deacetylase 2
ICE ;
Cocaine esterase ;
Carboxylesterase 2 ;
CE-2 ;
hCE-2 ;
Methylumbelliferyl-acetate deacetylase 2
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Background:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010],
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Function:
Catalytic activity:A carboxylic ester + H(2)O = an alcohol + a carboxylate.,Function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.,PTM:Glycosylated.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Monomer.,tissue specificity:Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.,
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Cellular Localization:
Endoplasmic reticulum lumen .
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Tissue Expression:
Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
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Research Areas:
>>Drug metabolism - other enzymes
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Reference Citation({{totalcount}})
Catalog: YT0874
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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