Catalog: YT0654
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$150.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
Caspase-12
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
50kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Caspase12 Polyclonal Antibody detects endogenous levels of Caspase12 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
50kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Caspase12. AA range:50-99
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Specificity:
Caspase12 Polyclonal Antibody detects endogenous levels of Caspase12 protein.
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Gene Name:
CASP12
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Protein Name:
caspase12
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Other Name:
CASP12 ;
Inactive caspase-12 ;
CASP-12
Inactive caspase-12 ;
CASP-12
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Background:
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents , the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However , in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq , Feb 2011] ,
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Function:
proteolysis , apoptosis , virus-infected cell apoptosis , ER-nuclear signaling pathway , response to unfolded protein , cell death , response to organic substance , regulation of cell death , programmed cell death , death , endoplasmic reticulum unfolded protein response , cellular response to stress , cellular response to unfolded protein , response to endoplasmic reticulum stress , regulation of apoptosis , regulation of programmed cell death , response to protein stimulus ,apoptosis in response to endoplasmic reticulum stress ,
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Cellular Localization:
endoplasmic reticulum ,IPAF inflammasome complex ,NLRP3 inflammasome complex ,AIM2 inflammasome complex ,
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Tissue Expression:
Research Areas:
>>Protein processing in endoplasmic reticulum ;
>>Apoptosis ;
>>NOD-like receptor signaling pathway ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Hepatitis B
>>Apoptosis ;
>>NOD-like receptor signaling pathway ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Hepatitis B
show all
Reference Citation({{totalcount}})
Catalog: YT0654
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$150.00
3 weeks
0
Add to cart
Collected
Collect
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