Catalog: YP1178
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
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Main Information
Target
Fos B
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
35kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-Fos B (S27) Polyclonal Antibody detects endogenous levels of Fos B protein only when phosphorylated at S27.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YLsSV
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
35kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human FosB around the phosphorylation site of Ser27. AA range:12-61
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Specificity:
Phospho-Fos B (S27) Polyclonal Antibody detects endogenous levels of Fos B protein only when phosphorylated at S27.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YLsSV
show all
Gene Name:
FOSB
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Protein Name:
Protein fosB
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Other Name:
FOSB ;
G0S3 ;
Protein fosB ;
G0/G1 switch regulatory protein 3
G0S3 ;
Protein fosB ;
G0/G1 switch regulatory protein 3
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Background:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
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Function:
Function:FosB interacts with Jun proteins enhancing their DNA binding activity.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Fos subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer.,
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Cellular Localization:
Nucleus .
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Tissue Expression:
[Isoform 11]: Expressed in the nucleus accumbens of the striatum (at protein level).
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Research Areas:
>>Osteoclast differentiation ;
>>IL-17 signaling pathway ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism
>>IL-17 signaling pathway ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1178
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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