The antiserum was produced against synthesized peptide derived from human APLP2 around the phosphorylation site of Tyr755. AA range:714-763

Phospho-APLP2 (Y755) Polyclonal Antibody detects endogenous levels of APLP2 protein only when phosphorylated at Y755.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PTyKY

APLP2

Amyloid-like protein 2

APLP2 ;
APPL2 ;
Amyloid-like protein 2 ;
APLP-2 ;
APPH ;
Amyloid protein homolog ;
CDEI box-binding protein ;
CDEBP

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],

Alternative products:Additional isoforms seem to exist,Function:May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.,PTM:The BPTI/Kunitz inhibitor domain is O-glycosylated.,similarity:Belongs to the APP family.,similarity:Contains 1 BPTI/Kunitz inhibitor domain.,subunit:Interacts with CPEB1.,tissue specificity:In placenta, brain, heart, lung, liver, kidney and endothelial tissues.,

Cell membrane ; Single-pass type I membrane protein . Nucleus .

Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.