Catalog: YP0688
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
Cdc25C
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, IHC, IF, ELISA
MW
80kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-Cdc25C (T48) Polyclonal Antibody detects endogenous levels of Cdc25C protein only when phosphorylated at T48.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PRtPV
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
80kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human CDC25C around the phosphorylation site of Thr48. AA range:14-63
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Specificity:
Phospho-Cdc25C (T48) Polyclonal Antibody detects endogenous levels of Cdc25C protein only when phosphorylated at T48.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PRtPV
show all
Gene Name:
CDC25C
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Protein Name:
M-phase inducer phosphatase 3
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Other Name:
CDC25C ;
M-phase inducer phosphatase 3 ;
Dual specificity phosphatase Cdc25C
M-phase inducer phosphatase 3 ;
Dual specificity phosphatase Cdc25C
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Background:
cell division cycle 25C(CDC25C) Homo sapiens This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015],
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Function:
Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed predominantly in G2 phase.,Function:Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.,PTM:Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase.,similarity:Belongs to the MPI phosphatase family.,similarity:Contains 1 rhodanese domain.,subunit:Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.,
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Cellular Localization:
Nucleus .
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Tissue Expression:
Colon carcinoma,Epithelium,Skin,Testis,
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Research Areas:
>>Cell cycle ;
>>Oocyte meiosis ;
>>Progesterone-mediated oocyte maturation ;
>>Human immunodeficiency virus 1 infection ;
>>MicroRNAs in cancer
>>Oocyte meiosis ;
>>Progesterone-mediated oocyte maturation ;
>>Human immunodeficiency virus 1 infection ;
>>MicroRNAs in cancer
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP0688
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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