This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
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Function:
sequence Caution:Translated as Trp.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains.,tissue specificity:Expressed in colon, small intestine, lung and kidney.,
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Cellular Localization:
Membrane ; Single-pass type I membrane protein .
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Tissue Expression:
Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B-cells, dendritic cells and macrophages. Not detected in T-cells.