Domain:The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.,Function:May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.,induction:By FGF signaling.,similarity:Belongs to the sprouty family.,similarity:Contains 1 SPR (sprouty) domain.,subcellular location:Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).,
show all
Cellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).