This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],
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Function:
Function:May be involved in intracellular vesicle traffic.,similarity:Belongs to the taxilin family.,subunit:Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A.,tissue specificity:Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.,
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Cellular Localization:
Nucleus membrane . Cytoplasm, cytosol .
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Tissue Expression:
Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.