Catalog: YN3598
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
Main Information
Target
C42S2
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF
MW
9kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:50-200; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of C42S2 at Human/Mouse/Rat
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
9kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human C42S2 AA range: 3-53
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Specificity:
This antibody detects endogenous levels of C42S2 at Human/Mouse/Rat
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Gene Name:
CDC42SE2 SPEC2
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Protein Name:
C42S2
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Function:
Domain:The CRIB domain mediates interaction with CDC42.,Function:Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.,miscellaneous:CDC42SE2 is mapped in the genomic region associated with schizophrenia.,similarity:Belongs to the CDC42SE/SPEC family.,similarity:Contains 1 CRIB domain.,subcellular location:Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.,subunit:Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.,tissue specificity:Widely expressed. Expressed at higher level in T lymphocytes. Highly expressed in CCRF-CEM T lymphocytes, Jurkat T lymphocytes, and Raji B lymphocytes compared (at protein level).,
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Cellular Localization:
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
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Reference Citation({{totalcount}})
Catalog: YN3598
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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