Catalog: YN3171
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
UBP21
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
60kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of UBP21 at Human/Mouse/Rat
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
60kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human UBP21 AA range: 50-100
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Specificity:
This antibody detects endogenous levels of UBP21 at Human/Mouse/Rat
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Gene Name:
USP21 USP23 PP1490
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Protein Name:
UBP21
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Other Name:
Ubiquitin carboxyl-terminal hydrolase 21 ;
Deubiquitinating enzyme 21 ;
Ubiquitin thioesterase 21 ;
Ubiquitin-specific-processing protease 21 ;
Deubiquitinating enzyme 21 ;
Ubiquitin thioesterase 21 ;
Ubiquitin-specific-processing protease 21 ;
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Database Link:
Background:
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016],
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Function:
Catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,Function:Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.,similarity:Belongs to the peptidase C19 family. USP21 subfamily.,tissue specificity:Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.,
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Cellular Localization:
Cytoplasm . Nucleus .
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Tissue Expression:
Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
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Research Areas:
>>Necroptosis
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YN3171
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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