This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015],
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Function:
Function:Vasorelaxant activity. Has a cGMP-stimulating activity.,similarity:Belongs to the natriuretic peptide family.,
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Cellular Localization:
Secreted.
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Tissue Expression:
[CNP-22]: In the kidney, predominantly expressed in the distal tubular cells (at protein level).