The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010],
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Function:
PTM:N-glycosylated.,similarity:To the N-terminal section of DKK-3.,
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Cellular Localization:
Secreted . Cytoplasmic vesicle, secretory vesicle, acrosome . Localized specifically to the crescent shaped acrosome at the apex of the sperm head. .
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Tissue Expression:
More highly expressed in adult testis than in fetal testis. Exclusively expressed in the testis (at protein level). Intense expression in stages II, III and IV of spermatogenesis, whereas expression is lower in stage I.