This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
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Function:
Domain:This inhibitor contains two inhibitory domains.,Function:Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.,similarity:Contains 1 BPTI/Kunitz inhibitor domain.,similarity:Contains 2 BPTI/Kunitz inhibitor domains.,tissue specificity:Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.,
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Cellular Localization:
Membrane ; Single-pass type I membrane protein .
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Tissue Expression:
Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.