Synthesized peptide derived from human protein . at AA range: 70-150

B2L10 Polyclonal Antibody detects endogenous levels of protein.

BCL2L10 BCLB

Bcl-2-like protein 10 (Bcl2-L-10) (Anti-apoptotic protein NrH) (Apoptosis regulator Bcl-B)

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008],

Function:Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.,similarity:Belongs to the Bcl-2 family.,subunit:Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.,tissue specificity:Widely expressed in adult tissues. Preferentially expressed in the lungs, the liver and the kidneys.,

Mitochondrion . Nucleus membrane . Endoplasmic reticulum . Cytoplasm, cytoskeleton, spindle . Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:27995898). Localization to MAMs is greatly reduced under apoptotic stress conditions (PubMed:27995898). .

Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.