This gene, which encodes a transcriptional repressor, is one of two paralogous X-linked homeobox-containing genes and is highly expressed in a variety of cancers. In addition, the encoded protein associates with the cell membrane and with microtubules, and is concentrated at the leading edge of migratory cells. [provided by RefSeq, Dec 2015],
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Function:
similarity:Belongs to the paired-like homeobox family. PEPP subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Testis. Not detected in epididymis nor placenta.,
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Cellular Localization:
Nucleus .
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Tissue Expression:
Testis. Not detected in epididymis nor placenta. In testis, mainly expressed in germ cells, but also detected in somatic cells such as Sertoli cells, Leydig cells and peritubular cells (PubMed:28171660).