The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003],
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Function:
Caution:Has been termed RASSF5 by Ref.1.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,subcellular location:Localized to microtubules in vascular endothelial cells.,tissue specificity:Widely expressed.,
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Cellular Localization:
Cytoplasm . Cytoplasm, cytoskeleton . Localized to microtubules in vascular endothelial cells.