Synthesized peptide derived from human Proliferating Cell Nuclear Antigen AA range: 1-100

The antibody can specifically recognize human PCNA protein. In western blotting of Hela, A431 and HEK293 cell lysates, the antibody can label a 30 kDa band corresponding to PCNA.

PCNA

Proliferating cell nuclear antigen

ATLD2 ;
cb16 ;
Cyclin ;
DNA polymerase delta auxiliary protein ;
etID36690.10 ;
fa28e03 ;
fb36g03 ;
HGCN8729 ;
MGC8367 ;
Mutagen-sensitive 209 protein ;
OTTHUMP00000030189 ;
OTTHUMP00000030190 ;
PCNA ;
Pcna/cyclin ;
PCNA_HUMAN ;
PCNAR ;
Polymerase delta accessory protein ;
ProlifeRating cell nuclear antigen ;
wu:fa28e03 ;
wu:fb36g03

PCNA is a 36 kDa nuclear protein related to cell cycle, which is necessary for cells to synthesize DNA. It is expressed in S phase, G1 phase and early G2 phase of proliferating cells and is the main marker of cell proliferation index. It is used to study the cell proliferation of malignant tumor and judge its malignant degree, which is of certain significance to the treatment and prognosis of tumor.

Disease:Antibodies are present in sera from patients with systemic lupus erythematosus.,Function:This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.,online information:PCNA entry,PTM:Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases RNF8 and SHPRH, which are required for DNA repair.,similarity:Belongs to the PCNA family.,subunit:Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B/WSTF; the interaction is direct.,

Nuclear

Tonsil/ Colon

>>DNA replication ;
>>Base excision repair ;
>>Nucleotide excision repair ;
>>Mismatch repair ;
>>Cell cycle ;
>>Tight junction ;
>>Hepatitis B