Synthesized peptide derived from human CD141 AA range: 50-150

The antibody can specifically recognize human CD141 protein.

THBD THRM

CD141

AHUS 6 ;
AHUS6 ;
BDCA 3 ;
BDCA3 ;
CD 141 ;
CD141 ;
CD141 antigen ;
Fetomodulin ;
Thbd ;
THPH12 ;
THRM ;
Thrombomodulin ;
TM ;
TRBM_HUMAN

CD141 is a 75 kDa transmembrane glycoprotein expressed in many normal tissues, such as arterial and venous endothelial cells and mesothelial cells. CD141 is not expressed in liver adenocarcinoma. CD141 protein is a sensitive marker of lymphatic endothelial cells and their tumors. It can be used to distinguish lung adenocarcinoma from malignant mesothelioma.

Disease:Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBDD) [MIM:188040]. THR-THBDD is a hemostatic disorder characterized by a tendency to thrombosis.,Function:Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.,online information:Thrombomodulin,online information:Thrombomodulin entry,PTM:N-glycosylated.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 6 EGF-like domains.,tissue specificity:Endothelial cells are unique in synthesizing thrombomodulin.,

Membranous

Endothelial cells are unique in synthesizing thrombomodulin.

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