Catalog: YM3796
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$160.00
3 weeks
0
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Collected
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Main Information
Target
Claudin-2
Host Species
Mouse
Reactivity
Human, Mouse, Rat
Applications
WB, IF, IHC
MW
25kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IF/ICC1:200-400; IHC
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of human Claudin-2
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
25kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
8H11
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human Claudin-2
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Specificity:
This antibody detects endogenous levels of human Claudin-2
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Gene Name:
CLDN2 PSEC0059 SP82 UNQ705/PRO1356
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Protein Name:
Claudin-2
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Other Name:
Claudin-2 ;
SP82 ;
SP82 ;
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Background:
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],
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Function:
Function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
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Cellular Localization:
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
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Tissue Expression:
Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,
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Research Areas:
>>Cell adhesion molecules ;
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM3796
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$160.00
3 weeks
0
Add to cart
Collected
Collect
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