Purified recombinant human Annexin A1 beta protein fragments expressed in E.coli.

This antibody detects endogenous levels of Annexin A1 and does not cross-react with related proteins.

anxa1

Annexin 1 ;
Annexin A1 ;
Annexin I ;
lipocortin I ;
Annexin I ;
Annexin-1 ;
AnnexinA1 ;
AnnexinI ;
ANX 1 ;
ANX A1 ;
ANX1 ;
ANXA 1 ;
ANXA1 ;
ANXA1 protein ;
ANXA1_HUMAN ;
Calpactin 2 ;
Calpactin II ;
Calpactin-2 ;
CalpactinII ;
Chromobindin 9 ;
Chromobindin-9 ;
Chromobindin9 ;
HGNC:533 ;
Lipocortin 1 ;
Lipocortin I ;
Lipocortin1 ;
LipocortinI ;
LPC 1 ;
LPC1 ;
p35 ;
Phospholipase A2 inhibitory protein.

This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014],

Domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,Function:Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.,PTM:Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.,similarity:Belongs to the annexin family.,similarity:Contains 1 annexin repeat.,similarity:Contains 2 annexin repeats.,similarity:Contains 4 annexin repeats.,subcellular location:Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages.,subunit:Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF.,

Nucleus . Cytoplasm . Cell projection, cilium . Cell membrane . Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Basolateral cell membrane . Apical cell membrane . Lateral cell membrane . Secreted . Secreted, extracellular space . Cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted, extracellular exosome . Cytoplasmic vesicle, secretory vesicle lumen . Cell projection, phagocytic cup . Early endosome . Cytoplasmic vesicle membrane ; Peripheral membrane protein . Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in the protein translocation from the cytoplasm into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). .

Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.