Purified recombinant fragment of human PR3 expressed in E. Coli.

PR3 Monoclonal Antibody detects endogenous levels of PR3 protein.

PRTN3

Myeloblastin

PRTN3 ;
MBN ;
Myeloblastin ;
AGP7 ;
C-ANCA antigen ;
Leukocyte proteinase 3 ;
PR-3 ;
PR3 ;
Neutrophil proteinase 4 ;
NP-4 ;
P29 ;
Wegener autoantigen

catalytic activity:Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.,function:Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.,online information:Proteinase 3 entry,similarity:Belongs to the peptidase S1 family. Elastase subfamily.,similarity:Contains 1 peptidase S1 domain.,

Catalytic activity:Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.,Function:Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.,online information:Proteinase 3 entry,similarity:Belongs to the peptidase S1 family. Elastase subfamily.,similarity:Contains 1 peptidase S1 domain.,

Cytoplasmic granule . Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Membrane raft ; Peripheral membrane protein ; Extracellular side . Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208). Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246). Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279). .

Expressed in polymorphonuclear leukocytes (at protein level) (PubMed:2033050, PubMed:7897245, PubMed:3198760). Expressed in neutrophils (at protein level) (PubMed:28240246, PubMed:18462208, PubMed:21193407, PubMed:22266279, PubMed:17244676). Expressed in differentiating neutrophils (PubMed:18462208).