Catalog: YM0520
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
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Collected
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Main Information
Target
Pinch-1
Host Species
Mouse
Reactivity
Human
Applications
WB, IF, FC, ELISA
MW
37kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Pinch-1 Monoclonal Antibody detects endogenous levels of Pinch-1 protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
37kD
Modification
Unmodified
Clonality
Monoclonal
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Antigen&Target Information
Immunogen:
Purified recombinant fragment of human Pinch-1 expressed in E. Coli.
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Specificity:
Pinch-1 Monoclonal Antibody detects endogenous levels of Pinch-1 protein.
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Gene Name:
LIMS1
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Protein Name:
LIM and senescent cell antigen-like-containing domain protein 1
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Other Name:
LIMS1 ;
PINCH ;
PINCH1 ;
LIM and senescent cell antigen-like-containing domain protein 1 ;
Particularly interesting new Cys-His protein 1 ;
PINCH-1 ;
Renal carcinoma antigen NY-REN-48
PINCH ;
PINCH1 ;
LIM and senescent cell antigen-like-containing domain protein 1 ;
Particularly interesting new Cys-His protein 1 ;
PINCH-1 ;
Renal carcinoma antigen NY-REN-48
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Background:
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010],
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Function:
Function:Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway.,similarity:Contains 5 LIM zinc-binding domains.,subunit:Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts (via LIM zinc-binding 1) with ILK. Interacts with SH3/SH2 adapter NCK2.,tissue specificity:In most tissues, except in the brain.,
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Cellular Localization:
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
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Tissue Expression:
Expressed in most tissues except in the brain.
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Reference Citation({{totalcount}})
Catalog: YM0520
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
Collect
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