Catalog: YM0255
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
ETS1
Host Species
Mouse
Reactivity
Human
Applications
WB, IHC, IF, FC, ELISA
MW
50kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
ETS1 Monoclonal Antibody detects endogenous levels of ETS1 protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
50kD
Modification
Unmodified
Clonality
Monoclonal
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Antigen&Target Information
Immunogen:
Purified recombinant fragment of human ETS1 expressed in E. Coli.
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Specificity:
ETS1 Monoclonal Antibody detects endogenous levels of ETS1 protein.
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Gene Name:
ETS1
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Protein Name:
Protein C-ets-1
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Other Name:
Ets-1 ;
ETS1 ;
EWSR2 ;
Protein C-ets-1 ;
p54
ETS1 ;
EWSR2 ;
Protein C-ets-1 ;
p54
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Background:
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],
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Function:
Disease:ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia.,Function:Transcription factor.,PTM:Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity.,PTM:Ubiquitinated; which induces proteasomal degradation.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Interacts with MAF and MAFB (By similarity). Binds to DAXX. Interacts with UBE2I.,
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Cellular Localization:
Cytoplasm . Nucleus . Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. .
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Tissue Expression:
Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.
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Research Areas:
>>Ras signaling pathway ;
>>Cellular senescence ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Renal cell carcinoma
>>Cellular senescence ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Renal cell carcinoma
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Signaling Pathway
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Catalog: YM0255
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
Collect
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