Catalog: YM0170
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
Csk
Host Species
Mouse
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IF, FC, ELISA
MW
51kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Csk Monoclonal Antibody detects endogenous levels of Csk protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
51kD
Modification
Unmodified
Clonality
Monoclonal
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Antigen&Target Information
Immunogen:
Purified recombinant fragment of human Csk expressed in E. Coli.
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Specificity:
Csk Monoclonal Antibody detects endogenous levels of Csk protein.
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Gene Name:
CSK
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Protein Name:
Tyrosine-protein kinase CSK
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Other Name:
CSK ;
Tyrosine-protein kinase CSK ;
C-Src kinase ;
Protein-tyrosine kinase CYL
Tyrosine-protein kinase CSK ;
C-Src kinase ;
Protein-tyrosine kinase CYL
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Database Link:
Background:
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,
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Function:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,
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Cellular Localization:
Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .
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Tissue Expression:
Expressed in lung and macrophages.
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Research Areas:
>>Epithelial cell signaling in Helicobacter pylori infection
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Reference Citation({{totalcount}})
Catalog: YM0170
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
Collect
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