Catalog: YM0097
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
CBX1
Host Species
Mouse
Reactivity
Human, Monkey
Applications
WB, IF, FC, ELISA
MW
21kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
CBX1 Monoclonal Antibody detects endogenous levels of CBX1 protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
21kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
2D2
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Antigen&Target Information
Immunogen:
Purified recombinant fragment of human CBX1 expressed in E. Coli.
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Specificity:
CBX1 Monoclonal Antibody detects endogenous levels of CBX1 protein.
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Gene Name:
CBX1
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Protein Name:
Chromobox protein homolog 1
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Other Name:
CBX1 ;
CBX ;
Chromobox protein homolog 1 ;
HP1Hsbeta ;
Heterochromatin protein 1 homolog beta ;
HP1 beta ;
Heterochromatin protein p25 ;
M31 ;
Modifier 1 protein ;
p25beta
CBX ;
Chromobox protein homolog 1 ;
HP1Hsbeta ;
Heterochromatin protein 1 homolog beta ;
HP1 beta ;
Heterochromatin protein p25 ;
M31 ;
Modifier 1 protein ;
p25beta
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Background:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008],
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Function:
Function:Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.,online information:Heterochromatin protein 1 entry,PTM:Not phosphorylated.,similarity:Contains 2 chromo domains.,subcellular location:Unassociated with chromosomes during mitosis.,subunit:Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts with SUV39H1 and SETDB1, SUV420H1 and SUV420H2. Interacts with PRDM6.,tissue specificity:In all adult and embryonic tissues.,
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Cellular Localization:
Nucleus . Unassociated with chromosomes during mitosis.
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Tissue Expression:
Reference Citation({{totalcount}})
Catalog: YM0097
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
Collect
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