Catalog: YF0116
Size
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Status
Qty.
10mg
$10,000.00
3 weeks
0
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Main Information
Target
IL-8RA
Host Species
Mouse
Reactivity
Human
Applications
FC
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
Formulation
PBS, pH 7.4
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration
0.5mg/ml
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PTF0106
Isotype
Mouse IgG2b/Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Endogenous
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Gene Name:
CXCR1 CMKAR1 IL8RA
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Protein Name:
C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)
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Other Name:
C-X-C chemokine receptor type 1 ;
CXC-R1 ;
CXCR-1 ;
CDw128a ;
High affinity interleukin-8 receptor A ;
IL-8R A ;
IL-8 receptor type 1 ;
CD antigen CD181 ;
CXC-R1 ;
CXCR-1 ;
CDw128a ;
High affinity interleukin-8 receptor A ;
IL-8R A ;
IL-8 receptor type 1 ;
CD antigen CD181 ;
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Background:
C-X-C motif chemokine receptor 1(CXCR1) Homo sapiens The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008],
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Function:
Function:Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.,online information:CXC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
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Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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Tissue Expression:
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Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>Epithelial cell signaling in Helicobacter pylori infection
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>Epithelial cell signaling in Helicobacter pylori infection
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Signaling Pathway
Organismal Systems >> Immune system >> Chemokine signaling pathway
Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Reference Citation({{totalcount}})
Catalog: YF0116
Size
Price
Status
Qty.
10mg
$10,000.00
3 weeks
0
Add to cart
Collected
Collect
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