Catalog: YT5516
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
Flt3-L
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
26kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Flt3-L Polyclonal Antibody detects endogenous levels of Flt3-L protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
26kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from the C-terminal region of human FLT3LG. AA range:171-220
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Specificity:
Flt3-L Polyclonal Antibody detects endogenous levels of Flt3-L protein.
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Gene Name:
FLT3LG
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Protein Name:
Fms-related tyrosine kinase 3 ligand
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Other Name:
FLT3LG ;
Fms-related tyrosine kinase 3 ligand ;
Flt3 ligand ;
Flt3L ;
SL cytokine
Fms-related tyrosine kinase 3 ligand ;
Flt3 ligand ;
Flt3L ;
SL cytokine
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Background:
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011],
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Function:
Function:Stimulates the proliferation of early hematopoietic cells. Synergizes well with a number of other colony stimulating factors and interleukins.,subunit:Homodimer (isoform 2).,
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Cellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
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Tissue Expression:
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Research Areas:
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Hematopoietic cell lineage ;
>>Pathways in cancer
>>Ras signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Hematopoietic cell lineage ;
>>Pathways in cancer
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Signaling Pathway
Organismal Systems >> Immune system >> Hematopoietic cell lineage
Human Diseases >> Cancer: overview >> Pathways in cancer
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Reference Citation({{totalcount}})
Catalog: YT5516
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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