This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014],
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Function:
Function:Induces hepatocellular proliferation. Has no biological effect on the heart.,similarity:Belongs to the heparin-binding growth factors family.,
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Cellular Localization:
Secreted .
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Tissue Expression:
Heart,
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Research Areas:
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Regulation of actin cytoskeleton ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Melanoma ;
>>Breast cancer ;
>>Gastric cancer