The antiserum was produced against synthesized peptide derived from the N-terminal region of human IFNAR2. AA range:41-90

IFN-αR2 Polyclonal Antibody detects endogenous levels of IFN-αR2 protein.

IFNAR2

Interferon alpha/beta receptor 2

IFNAR2 ;
IFNABR ;
IFNARB ;
Interferon alpha/beta receptor 2 ;
IFN-R-2 ;
IFN-alpha binding protein ;
IFN-alpha/beta receptor 2 ;
Interferon alpha binding protein ;
Type I interferon receptor 2

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Disease:Defects in IFNAR2 are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,Function:Receptor for interferons alpha and beta. Isoform 1 and isoform 3 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.,PTM:Upon binding, it is phosphorylated on tyrosine residues.,similarity:Belongs to the type II cytokine receptor family.,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Secreted .

Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.

>>Cytokine-cytokine receptor interaction ;
>>PI3K-Akt signaling pathway ;
>>Necroptosis ;
>>Osteoclast differentiation ;
>>Toll-like receptor signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>JAK-STAT signaling pathway ;
>>Natural killer cell mediated cytotoxicity ;
>>Hepatitis C ;
>>Measles ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Coronavirus disease - COVID-19 ;
>>Pathways in cancer