Synthesized peptide derived from V-ATPase D . at AA range: 70-150

V-ATPase D Polyclonal Antibody detects endogenous levels of V-ATPase D protein.

ATP6V1D

V-type proton ATPase subunit D

ATP6V1D ;
ATP6M ;
VATD ;
V-type proton ATPase subunit D ;
V-ATPase subunit D ;
V-ATPase 28 kDa accessory protein ;
Vacuolar proton pump subunit D

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008],

Function:Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.,similarity:Belongs to the V-ATPase D subunit family.,subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).,

Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell projection, cilium . Localizes to centrosome and the base of the cilium. .

Bone marrow,Brain,Heart,Pancreatic adenocarcinoma,Pituitary,Placent

>>Oxidative phosphorylation ;
>>Metabolic pathways ;
>>Phagosome ;
>>mTOR signaling pathway ;
>>Synaptic vesicle cycle ;
>>Collecting duct acid secretion ;
>>Vibrio cholerae infection ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Human papillomavirus infection ;
>>Rheumatoid arthritis