The antiserum was produced against synthesized peptide derived from human SDF-1. AA range:44-93

SDF-1 Polyclonal Antibody detects endogenous levels of SDF-1 protein.

CXCL12

Stromal cell-derived factor 1

CXCL12 ;
SDF1 ;
SDF1A ;
SDF1B ;
Stromal cell-derived factor 1 ;
SDF-1 ;
hSDF-1 ;
C-X-C motif chemokine 12 ;
Intercrine reduced in hepatomas ;
IRH ;
hIRH ;
Pre-B cell growth-stimulating factor ;
PBSF

C-X-C motif chemokine ligand 12(CXCL12) Homo sapiens This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],

Function:Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites.,online information:SDF-1 entry,PTM:Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,

Secreted.

Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.

>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway ;
>>NF-kappa B signaling pathway ;
>>Axon guidance ;
>>Leukocyte transendothelial migration ;
>>Intestinal immune network for IgA production ;
>>Regulation of actin cytoskeleton ;
>>Human cytomegalovirus infection ;
>>Pathways in cancer ;
>>Rheumatoid arthritis