The antiserum was produced against synthesized peptide derived from human GRM1. AA range:251-300

mGluR1 Polyclonal Antibody detects endogenous levels of mGluR1 protein.

GRM1

Metabotropic glutamate receptor 1

GRM1 ;
GPRC1A ;
MGLUR1 ;
Metabotropic glutamate receptor 1 ;
mGluR1

glutamate metabotropic receptor 1(GRM1) Homo sapiens This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],

Function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP.,

Cell membrane ; Multi-pass membrane protein .

Detected in brain.

>>Calcium signaling pathway ;
>>FoxO signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Gap junction ;
>>Long-term potentiation ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Long-term depression ;
>>Taste transduction ;
>>Estrogen signaling pathway ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases