Catalog: YT2602
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
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Main Information
Target
LTβR
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IF, ELISA
MW
50kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
LTβR Polyclonal Antibody detects endogenous levels of LTβR protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
50kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human LTBR. AA range:11-60
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Specificity:
LTβR Polyclonal Antibody detects endogenous levels of LTβR protein.
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Gene Name:
LTBR
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Protein Name:
Tumor necrosis factor receptor superfamily member 3
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Other Name:
LTBR ;
D12S370 ;
TNFCR ;
TNFR3 ;
TNFRSF3 ;
Tumor necrosis factor receptor superfamily member 3 ;
Lymphotoxin-beta receptor ;
Tumor necrosis factor C receptor ;
Tumor necrosis factor receptor 2-related protein ;
Tumor necrosis factor receptor type II
D12S370 ;
TNFCR ;
TNFR3 ;
TNFRSF3 ;
Tumor necrosis factor receptor superfamily member 3 ;
Lymphotoxin-beta receptor ;
Tumor necrosis factor C receptor ;
Tumor necrosis factor receptor 2-related protein ;
Tumor necrosis factor receptor type II
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Background:
lymphotoxin beta receptor(LTBR) Homo sapiens This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012],
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Function:
Function:Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein.,
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Cellular Localization:
Membrane; Single-pass type I membrane protein.
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Tissue Expression:
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Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>NF-kappa B signaling pathway ;
>>HIF-1 signaling pathway ;
>>Intestinal immune network for IgA production ;
>>Human T-cell leukemia virus 1 infection ;
>>Viral carcinogenesis
>>Viral protein interaction with cytokine and cytokine receptor ;
>>NF-kappa B signaling pathway ;
>>HIF-1 signaling pathway ;
>>Intestinal immune network for IgA production ;
>>Human T-cell leukemia virus 1 infection ;
>>Viral carcinogenesis
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Signaling Pathway
Organismal Systems >> Immune system >> Intestinal immune network for IgA production
Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway
Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Reference Citation({{totalcount}})
Catalog: YT2602
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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