Catalog: YT2333
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
IL-3Rβ
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
125kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
IL-3Rβ Polyclonal Antibody detects endogenous levels of IL-3Rβ protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
125kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human IL-3R beta. AA range:559-608
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Specificity:
IL-3Rβ Polyclonal Antibody detects endogenous levels of IL-3Rβ protein.
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Gene Name:
CSF2RB IL3RB IL5RB
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Protein Name:
Cytokine receptor common subunit beta
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Other Name:
CSF2RB ;
IL3RB ;
IL5RB ;
Cytokine receptor common subunit beta ;
CDw131 ;
GM-CSF/IL-3/IL-5 receptor common beta subunit ;
CD antigen CD131
IL3RB ;
IL5RB ;
Cytokine receptor common subunit beta ;
CDw131 ;
GM-CSF/IL-3/IL-5 receptor common beta subunit ;
CD antigen CD131
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Background:
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008],
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Function:
Disease:Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.,Domain:The box 1 motif is required for JAK interaction and/or activation.,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,Function:High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.,
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Cellular Localization:
Membrane; Single-pass type I membrane protein.
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Tissue Expression:
Placenta,
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Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>Apoptosis ;
>>JAK-STAT signaling pathway ;
>>Pathways in cancer
>>Apoptosis ;
>>JAK-STAT signaling pathway ;
>>Pathways in cancer
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Apoptosis
Human Diseases >> Cancer: overview >> Pathways in cancer
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Reference Citation({{totalcount}})
Catalog: YT2333
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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