The antiserum was produced against synthesized peptide derived from human GA45G. AA range:101-150

GADD 45γ Polyclonal Antibody detects endogenous levels of GADD 45γ protein.

GADD45G

Growth arrest and DNA damage-inducible protein GADD45 gamma

GADD45G ;
CR6 ;
DDIT2 ;
Growth arrest and DNA damage-inducible protein GADD45 gamma ;
Cytokine-responsive protein CR6 ;
DNA damage-inducible transcript 2 protein ;
DDIT-2

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008],

Function:Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.,similarity:Belongs to the GADD45 family.,subunit:Interacts with GADD45GIP1.,

nucleus,cytoplasm,

>>MAPK signaling pathway ;
>>NF-kappa B signaling pathway ;
>>FoxO signaling pathway ;
>>Cell cycle ;
>>p53 signaling pathway ;
>>Apoptosis ;
>>Cellular senescence ;
>>Epstein-Barr virus infection ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Colorectal cancer ;
>>Pancreatic cancer ;
>>Endometrial cancer ;
>>Glioma ;
>>Thyroid cancer ;
>>Basal cell carcinoma ;
>>Melanoma ;
>>Chronic myeloid leukemia ;
>>Small cell lung cancer ;
>>Non-small cell lung cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer