Catalog: YT1284
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
DAN
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, IHC, IF, ELISA
MW
19kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
DAN Polyclonal Antibody detects endogenous levels of DAN protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
19kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human NBL1. AA range:131-180
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Specificity:
DAN Polyclonal Antibody detects endogenous levels of DAN protein.
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Gene Name:
NBL1
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Protein Name:
Neuroblastoma suppressor of tumorigenicity 1
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Other Name:
NBL1 ;
DAN ;
DAND1 ;
Neuroblastoma suppressor of tumorigenicity 1 ;
DAN domain family member 1 ;
Protein N03 ;
Zinc finger protein DAN
DAN ;
DAND1 ;
Neuroblastoma suppressor of tumorigenicity 1 ;
DAN domain family member 1 ;
Protein N03 ;
Zinc finger protein DAN
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Background:
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013],
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Function:
Disease:Defects in NBL1 are possibly the cause of the development and/or progression of human neuroblastoma.,Function:Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.,similarity:Belongs to the DAN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,tissue specificity:Most abundant in normal lung and meningioma.,
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Cellular Localization:
Secreted.
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Tissue Expression:
Most abundant in normal lung and meningioma.
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Research Areas:
>>TGF-beta signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT1284
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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