The antiserum was produced against synthesized peptide derived from human ATF6B. AA range:401-450

ATF-6β Polyclonal Antibody detects endogenous levels of ATF-6β protein.

ATF6B

Cyclic AMP-dependent transcription factor ATF-6 beta

ATF6B ;
CREBL1 ;
G13 ;
Cyclic AMP-dependent transcription factor ATF-6 beta ;
cAMP-dependent transcription factor ATF-6 beta ;
Activating transcription factor 6 beta ;
ATF6-beta ;
Protein G13 ;
cAMP response element-binding protein-related protein ;

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],

Domain:The basic domain functions as a nuclear localization signal.,Domain:The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.,Function:Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.,PTM:During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.,PTM:N-glycosylated.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC).,tissue specificity:Ubiquitous.,

Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. .

>>cGMP-PKG signaling pathway ;
>>Protein processing in endoplasmic reticulum ;
>>PI3K-Akt signaling pathway ;
>>Longevity regulating pathway ;
>>Adrenergic signaling in cardiomyocytes ;
>>TNF signaling pathway ;
>>Dopaminergic synapse ;
>>Insulin secretion ;
>>Estrogen signaling pathway ;
>>Thyroid hormone synthesis ;
>>Aldosterone synthesis and secretion ;
>>Relaxin signaling pathway ;
>>Cortisol synthesis and secretion ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Prion disease ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Viral carcinogenesis ;
>>Chemical carcinogenesis - receptor activation