Catalog: YP1286
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
CARD11 Phospho Ser652
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
130kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse Rat CARD11 (phospho-Ser652)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
130kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human CARD11 (Ser652)
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Specificity:
This antibody detects endogenous levels of Human Mouse Rat CARD11 (phospho-Ser652)
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Gene Name:
CARD11 CARMA1
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Protein Name:
Caspase recruitment domain-containing protein 11
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Other Name:
CARD11 ;
CARMA1 ;
Caspase recruitment domain-containing protein 11 ;
CARD-containing MAGUK protein 1 ;
Carma 1
CARMA1 ;
Caspase recruitment domain-containing protein 11 ;
CARD-containing MAGUK protein 1 ;
Carma 1
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Background:
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],
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Function:
Caution:Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.,Function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.,similarity:Contains 1 CARD domain.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:CARD11 and BCL10 bind to each other by CARD-CARD interaction.,tissue specificity:Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.,
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Cellular Localization:
Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts. .
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Research Areas:
>>NF-kappa B signaling pathway ;
>>T cell receptor signaling pathway ;
>>B cell receptor signaling pathway
>>T cell receptor signaling pathway ;
>>B cell receptor signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1286
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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