The antiserum was produced against synthesized peptide derived from human RSK1/2/3/4 around the phosphorylation site of Ser221/227/S218/232. AA range:191-240

This antibody detects endogenous levels of RSK1/2/3/4 only when phosphorylated at Human:S221/227/S218/232, Mouse:S221/227/S218/252..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AYsFC

RPS6KA1

Ribosomal protein S6 kinase alpha-1

RPS6KA1 ;
MAPKAPK1A ;
RSK1 ;
Ribosomal protein S6 kinase alpha-1 ;
S6K-alpha-1 ;
90 kDa ribosomal protein S6 kinase 1 ;
p90-RSK 1 ;
p90RSK1 ;
p90S6K ;
MAP kinase-activated protein kinase 1a ;
MAPK-activated protein kinase 1a ;
MAPKAP kinase 1a ;
MAPKAP

ribosomal protein S6 kinase A1(RPS6KA1) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-380, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,

Nucleus. Cytoplasm.

Colon,Epithelium,

>>MAPK signaling pathway ;
>>Oocyte meiosis ;
>>mTOR signaling pathway ;
>>Thermogenesis ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Insulin resistance ;
>>Yersinia infection ;
>>Chemical carcinogenesis - receptor activation