The antiserum was produced against synthesized peptide derived from human ICAM-1 around the phosphorylation site of Tyr512. AA range:479-528

Phospho-ICAM-1 (Y512) Polyclonal Antibody detects endogenous levels of ICAM-1 protein only when phosphorylated at Y512.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KKyRL

ICAM1

Intercellular adhesion molecule 1

ICAM1 ;
Intercellular adhesion molecule 1 ;
ICAM-1 ;
Major group rhinovirus receptor ;
CD antigen CD54

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008],

Function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.,

Membrane; Single-pass type I membrane protein.

Blood,Kidney,Liver,Melanoma,Plasma,

>>NF-kappa B signaling pathway ;
>>Cell adhesion molecules ;
>>Natural killer cell mediated cytotoxicity ;
>>TNF signaling pathway ;
>>Leukocyte transendothelial migration ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>African trypanosomiasis ;
>>Malaria ;
>>Staphylococcus aureus infection ;
>>Influenza A ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Rheumatoid arthritis ;
>>Viral myocarditis ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis