Catalog: YN2407
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
SIAL
Host Species
Rabbit
Reactivity
Human, Rat, Mouse
Applications
WB, ELISA
MW
34kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
SIAL Polyclonal Antibody detects endogenous levels of protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
34kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human protein . at AA range: 230-310
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Specificity:
SIAL Polyclonal Antibody detects endogenous levels of protein.
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Gene Name:
IBSP BNSP
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Protein Name:
Bone sialoprotein 2 (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Integrin-binding sialoprotein)
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Background:
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008],
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Function:
Function:Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.,miscellaneous:It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.,PTM:N-glycosylated; glycans consist of sialated and core-fucosylated bi-, tri- and tetraantennary chains.,PTM:O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc.,PTM:Sulfated on either Tyr-313 or Tyr-314.,
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Cellular Localization:
Secreted.
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Research Areas:
>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Human papillomavirus infection
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Human papillomavirus infection
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YN2407
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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