Synthesized peptide derived from part region of human protein AA range: 1-100

CR3L3 Polyclonal Antibody detects endogenous levels of protein.

CREB3L3 CREBH HYST1481

Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],

Function:Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.,PTM:Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Binds DNA as a dimer (By similarity). Probably homodimerizes. Probably forms a heterodimer with atf6. Interacts with atf6.,tissue specificity:Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.,

Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Adrenergic signaling in cardiomyocytes ;
>>TNF signaling pathway ;
>>Thermogenesis ;
>>Cholinergic synapse ;
>>Dopaminergic synapse ;
>>Insulin secretion ;
>>Estrogen signaling pathway ;
>>Melanogenesis ;
>>Thyroid hormone synthesis ;
>>Glucagon signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Relaxin signaling pathway ;
>>Cortisol synthesis and secretion ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Insulin resistance ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Vasopressin-regulated water reabsorption ;
>>Huntington disease ;
>>Prion disease ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Viral carcinogenesis ;
>>Chemical carcinogenesis - receptor activation ;
>>Prostate cancer