Catalog: YM9058
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
B2MG
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
14kD (Calculated)
12kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:2000-1:10000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
14kD
MW(Observed)
12kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT1216R
Isotype
IgG,Kappa
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
B2M CDABP0092 HDCMA22P
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Protein Name:
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
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Background:
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014],
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Function:
Disease:Defects in B2M are the cause of hypercatabolic hypoproteinemia [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.,Function:Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.,online information:Beta-2-microglobulin entry,PTM:Glycation of Ile-21 is observed in long-term hemodialysis patients.,similarity:Belongs to the beta-2-microglobulin family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,
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Cellular Localization:
Secreted . Cell surface . Detected in serum and urine (PubMed:1336137, PubMed:7554280). .; (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553). .
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Tissue Expression:
Research Areas:
>>Antigen processing and presentation ;
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection
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Catalog: YM9058
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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