Endogenous

PPIF

Peptidyl-prolyl cis-trans isomerase F mitochondrial

PPIF ;
CYP3 ;
Peptidyl-prolyl cis-trans isomerase F ;
mitochondrial ;
PPIase F ;
Cyclophilin F ;
Rotamase F

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008],

Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,Function:PPIases accelerate the folding of proteins.,Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Contains 1 PPIase cyclophilin-type domain.,

Mitochondrion matrix .

Blood,Cord blood,Ovary,

>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>Neutrophil extracellular trap formation ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Toxoplasmosis ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Diabetic cardiomyopathy