Endogenous

MME EPN

Neprilysin

MME ;
EPN ;
Neprilysin ;
Atriopeptidase ;
Common acute lymphocytic leukemia antigen ;
CALLA ;
Enkephalinase ;
Neutral endopeptidase 24.11 ;
NEP ;
Neutral endopeptidase ;
Skin fibroblast elastase ;
SFE ;
CD10

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this

Catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,Disease:Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.,enzyme regulation:Inhibited in a dose dependent manner by opiorphin.,Function:Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).,similarity:Belongs to the peptidase M13 family.,

Membrane

>>Rap1 signaling pathway ;
>>Adherens junction ;
>>Leukocyte transendothelial migration