Ki-67 is a proliferating cell related nuclear protein, which is closely related to mitosis. It can recognize cells in G1, S, G2 and M phases except G0 phase. It is mainly used to judge the cell proliferation index. Ki-67 proliferation index is closely related to the degree of differentiation, invasion, metastasis and prognosis of many tumors. Therefore, it is also one of the important reference indexes for the prognosis of some malignant tumors. It is widely used as a marker of various malignant tumors and in tumor research.
show all
Function:
developmental stage:Expression of this antigen occurs preferentially during late G1, S, G2 and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected.,Function:Thought to be required for maintaining cell proliferation.,online information:Ki-67 entry,similarity:Contains 1 FHA domain.,subcellular location:Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.,subunit:Interacts with KIF15. Binds through the FHA domain to MKI67IP.,