Synthesized peptide derived from human COX-2 (cyclooxygenase-2) AA range: 500-604

The antibody can specifically recognize human COX-2 protein. In western blotting of Hela and A549 cell lysates, the antibody can label a 70 kDa band corresponding to COX-2.

PTGS2 COX2

Prostaglandin G/H synthase 2 (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)

COX 2 ;
COX-2 ;
COX2 ;
Cyclooxygenase 2 ;
Cyclooxygenase 2b ;
Cyclooxygenase ;
Cyclooxygenase-2 ;
Cyclooxygenase2 ;
fj02a10 ;
Glucocorticoid-regulated inflammatory cyclooxygenase ;
Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase ;
GRIPGHS ;
hCox 2 ;
Macrophage activation-associated marker protein P71/73 ;
OTTHUMP00000033524 ;
PES-2 ;
PGG/HS ;
PGH synthase 2 ;
PGH2_HUMAN ;
PGHS 2 ;
PGHS-2 ;
PGHS2 ;
PHS 2 ;
PHS II ;
PHS2 ;
Prostaglandin endoperoxide synthase 2 ;
prostaglandin G/H synthase and cyclooxygenase ;
Prostaglandin endoperoxide synthase 2 ;
Prostaglandin G/H synthase 2 ;
Prostaglandin G/H synthase 2 precursor ;
Prostaglandin G/H synthase and cyclooxygenase ;
Prostaglandin G/H synthase ;
Prostaglandin H2 synthase 2 ;
prostaglandin-endoperoxide synthase 2 ;
prostaglandin G/H synthase and cyclooxygenase ;
Prostaglandin-endoperoxide synthase 2 ;
PTGS2 ;
ptgs2a ;
TIS10 ;
TIS10 protein ;
unp1239 ;
wu:fj02a10

COX has two isomeric forms of COX-1 and COX-2. It is a membrane-bound protease involved in the conversion of arachidonic acid to prostaglandins. COX-2 is an inducible enzyme that participates in the expression of cell growth factors, tumor promoting factors and cytokines, and is highly expressed in breast, lung, and colon cancers. It is mainly used in tumor research and is one of the targets of tumor therapy.

Catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,Disease:Likely to play a role in inflammatory diseases such as rheumatoid arthritis.,Function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.,induction:By cytokines and mitogens.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,

Cytoplasmic

>>Arachidonic acid metabolism ;
>>Metabolic pathways ;
>>NF-kappa B signaling pathway ;
>>VEGF signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>IL-17 signaling pathway ;
>>TNF signaling pathway ;
>>Retrograde endocannabinoid signaling ;
>>Serotonergic synapse ;
>>Ovarian steroidogenesis ;
>>Oxytocin signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Leishmaniasis ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - DNA adducts ;
>>MicroRNAs in cancer ;
>>Small cell lung cancer