Catalog: YM4531
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
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Collected
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Main Information
Target
CDKN2B
Host Species
Mouse
Reactivity
Human
Applications
WB, IF, ELISA
MW
15kD (Calculated)
15kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
This antibody detects endogenous levels of p15 INK protein.
Purification
Protein G
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
15kD
MW(Observed)
15kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PTR2192
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human p15 INK (PTR2192) AA range: 50-138
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Specificity:
This antibody detects endogenous levels of p15 INK protein.
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Gene Name:
CDKN2B MTS2
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Protein Name:
Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)
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Background:
cyclin dependent kinase inhibitor 2B(CDKN2B) Homo sapiens This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008],
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Function:
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
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Cellular Localization:
Cytoplasmic
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Tissue Expression:
Signaling Pathway
Cellular Processes >> Cell growth and death >> Cell cycle
Cellular Processes >> Cell growth and death >> Cellular senescence
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Small cell lung cancer
Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway
Environmental Information Processing >> Signal transduction >> FoxO signaling pathway
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Catalog: YM4531
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
Collect
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